20.12.22:Alternative therapies for Helicobacter pylori: probiotics and phytomedicine

Prelegent: prof. Koula Doukani (Ibn Khaldoun University of Tiaret/Algeria)

Temat: Alternative therapies for_Helicobacter pylori: probiotics and phytomedicine

Streszczenie: Helicobacter pylori is a bacterium that was accidentally discovered in 1982 by two Australian researchers, Robin Warren (pathologist) and Barry Marshall (gastroenterologist), who isolated and cultured organisms from human stomachs. It is involved in the genesis of the majority of chronic gastritis, in ulcerative, duodenal or gastric diseases, in non-ulcer dyspepsia or indirectly in the occurrence of lymphoma or gastric cancer.Since 80% of peptic ulcers are caused by H. pylori infections, even though in many infected humans the disease remains asymptomatic. Helicobacter pylori is a very common bacterium (found in 50% of humans). It lives exclusively in the human stomach and is the only known bacterium that can survive in such an acidic environment. This bacteriuminfects more than half of the world’s population; its prevalence varies according to the populations, even within the same country. In Algeria, the high prevalence of H. pylori and the spread of this bacterium are alarming.

H. pylori is typically treated with a combination of antibiotics plus a proton pump inhibitor (PPI). Faced to numerous obstacles presented by the use of available antibacterials such as antibiotic resistance which is the most important factor leading to failed Helicobacter pylori eradication therapy,it is essential to seek new effective antibacterial substances with a broad spectrum of action. One of the strategies for researchers consists in exploring the plants used in traditional medicine and the probiotics whichhave aroused the interest of doctors and nutritionists because of their lack of pathogenicity and their reputation for protection against gastroenteritis.

Nowadays, we understand more and more, that the active principles of plants medicinal products are often related to the products of secondary metabolites, which are widely used in therapy, as anti-inflammatory preventive agents, antimicrobial, antiseptics, diuretics, But mainly antioxidant. Also probiotics increase the barrier function of the intestinal mucosa, for example by increasing the production of mucus or IgA type antibodies and have direct antimicrobial effects, taking the place of pathogenic bacteria (phenomenon of competition) and preventing their adhesion to the intestinal wall.

For these reasons mentioned above, researchers are focusing on the effect of probiotic and/ prebiotics (plants extract) and their combined effect on H. pylori. 

Data i godzina: 20.12.2022, godzina 12:00

Miejsce: sala AB-3002